Optical Bioimaging and Therapy

In 1665, Britain physicist Robert Hooke first observed the plant cells upon a cork slice. Since then, scientists have never stopped pursuing more advanced technology for optical bioimaging, facilitating progress in biological and medical fields. 21st century, bioimaging has become important analytical tool research of life science created multiple breakthroughs on field which were awarded Nobel Prize, such as super-resolution fluorescence microscopy (2014) applications green fluorescent protein (2008). recent years, along with flourishment nanotechnology nanomaterials, enormous promotion cancer theranostics been produced. First published 2013, Advanced Optical Materials is an interdisciplinary journal top quality photonics, plasmonics, metamaterials, more. Up till now, over 5,000 scientific articles reported their great contributions to development fields materials science. To celebrate 10th anniversary publication witness achievements, this special issue “Optical Bioimaging Therapy” includes 20 highlight progresses flourishing phototherapy. near-infrared (NIR) between 700 1,700 nm regarded “tissue-transparent” window biomedical field. Till various biomaterials developed high-efficiency NIR light energy conversion therapy, down/up-conversion long-lasting phosphors, semiconductor quantum dots, carbon dots polymer (carbonized) organic etc. Even success, so far, new are still being exploited. For example, two kinds ytterbium dimers prepared by Loïc J. Charbonnière group (see article 2202307), exhibit two-photon cooperative luminescence upconversion. Various material-decorated photosynthetic microorganisms intrinsic oxygenation autofluorescence variety (Bengang Xing et al., see 2203038). Apart from innovation material, other key concern surface modification materials, affects colloidal dispersibility, stability intensity water physiological buffers. Hence, Haichun Liu al. summarized latest advances how adapt lanthanide-doped luminescent nanoparticles (LNPs) aqueous medium, ways utilize interaction LNPs particularly focusing nanomedicine 2200513). can provide visualization results many parameters or events, thus possesses broad application prospects. instance, Daniel Jaque co-workers achieved reliable intranuclear thermal measurements utilizing (GFP) based thermometers 2201664). The Ka-Leung Wong Eu(III)-based complex small-molecule imaging agent shows off–on realized real-time quantitative analysis bioorthogonal reaction 2203057). vivo second-near-infrared (NIR-II, 1000–1700 nm) reduced photon scattering received increasing attention, allows high spatiotemporal resolution depth. Niko Hildebrandt NIR-II-emitting ultrasmall gold nanoclusters encapsulated accomplish 3.8 × 106 M–1 cm–1 brightnesses 2201474). Furthermore, themes about windows I II phosphors theranostic (Ru-Shi 2202061) NIR-II lanthanide nanocrystals improved (Fan Zhang 2202039) reviewed, respectively, having significant meaning further bioimaging. Persistent also attracted wide range interests, exception Bruno Viana presented persistent at after charging 980 laser, helps increase rechargeability capacity excitation wavelength fully inside 2201468). addition, Piaoping Yang highlighted inorganic afterglow containing mechanisms, properties, modulating methods, 2202382). Similarly, comprehensive overview semiconducting region therapeutics Changfeng Wu his 2202052). Cancer phototherapy method that uses achieve noninvasive tumor treatment usually photothermal therapy (PTT), photodynamic (PDT) controlled drug release. Due its low requirements deeper penetration comparison visible light, guided better biosecurity lower tissue damage. issue, 5 prominently displayed, including bismuth-based (Chuanbin Mao 2201482), manganese-silicon nanocomposite (Jun Lin 2202022), metal-organic frameworks (Yanli Zhao 2201043), upconversion (UCNPs) (Chunxia Li 2202060) copper peroxide nanomaterials (Ping'an Ma 2202040). As representative responsive UCNPs modify irradiation through multiple-photon process, widely applied imaging, delivery, antitumor therapy. Here, 3 review recommended, NIR-to-ultraviolet (Feng Wang 2201716), heterostructures combining framework (Guanying Chen 2202122) bacteria-targeted (Xueyuan 2202386). Moreover, thanks character, diagnosis brain diseases (Yinghui 2202888). This highlights advance synthetic high-quality theranostics. By means efficient transfer process suitable modification, labeling light-triggered release, sensing, integrated form multifunctional platform within one single item. These improvements promising exceed cellular level preclinical trials, be clinical translation. summary, honor greatly promoted especially last decade. we would like express our gratitude all authors supports contributions. We wish readers derive enjoyment inspiration themed issue. Jun B.S. M.S. degrees Jilin University, Ph.D. degree Changchun Institute Applied Chemistry (1995). His postdoctoral studies performed City University Hong Kong (1996), New (Germany, 1997), Virginia Commonwealth (USA, 1998), Orleans 1999). He working Professor CIAC since 2000. interests include bulk- nanostructured composite together display, lighting, Bengang Nanjing 2000, he did HKUST, UCLA, Stanford University. joined Nanyang Technological (NTU) 2006. Currently, full professor School Chemistry, Chemical Engineering Biotechnology, Singapore. interest interfaces bio-fluorescence chemical biology nano-medicines, mainly “smart” small molecules, peptides, nanoprobes monitoring diagnosis. Dayong Jin obtained PhD Macquarie 2007. At Macquarie, was Lecturer 2010, Senior Associate 2014, 2015. UTS 2015, Chair Professor, Distinguished 2017. established Australian Industry Transformation Research Hub (ARC IDEAL Hub), Biomedical & Devices (IBMD), transform phonics into disruptive biotechnologies. Clarivate Highly Cited Researcher, fellow Academy Technology Engineering, ARC Laureate Fellow, expertise covering engineering, nanotechnology, microscopy, microfluidics, chemistry, enable rapid detection molecules.